Objective: To investigate the clinical effect of huaiqihuang granule and its effect on MMPs/TIMPs of liver cancer.Methods: Review the clinical data of 90 cases of liver cancer patients in our hospital, and set those who received conventional liver protection therapy as liver cancer group, and those who received low-dose locust berry yellow. A low-dose group of patients treated with pellets and a high-dose group of 30 patients each treated with locust berry yellow pellets. 15 healthy patients were selected as healthy control group. The levels of ALT,AST and AFP were detected by automatic biochemical analyzer.The contents of MMP-2、MMP-9、TIMP-2 and TIMP-1 in serum of the subjects were detected by ELISA, and the symptom improvement and quality of life (KPS) score of each group were observed.Results: The levels of ALT, AST, and AFP gradually decreased in the liver cancer group, low-dose group, and high-dose group, and the difference was statistically significant (P<0.05). Serum MMP-2 and MMP-9 gradually decreased in the hepatocellular carcinoma, low and high-dose groups (P<0.05), and serum TIMP-2 and TIMP-1 levels gradually increased (P<0.05). The improvement rate of clinical symptoms was 80.0% in the high-dose group,which was significantly higher than that in the low-dose group and the liver cancer group (P<0.05). The KPS score in the high-dose group was higher than in the low dose group and the liver cancer group (P<0.05).Conclusion: Huaiqihuang granules can effectively improve liver function and the clinical efficacy in the treatment of liver cancer,possibly by reducing the levels of MMPs and TIMPs,it is worthy of wide clinical application.
Key words
Huai qi huang granules /
cancer /
clinical effects /
MMPs/TIMPs
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