Objective: To investigate the clinical effect of retention enema therapy with traditional Chinese medicine for the treatment of liver cirrhosis related endotoxemia. Methods: One hundred patients with liver cirrhosis related endotoxemia (67 males and 33 females, aged 37~75 years) were randomly divided into observation group and control group. The observation group was given retention enema therapy with a traditional Chinese medicine compound (water decoction), once every other day for 14 days, while the control group was not treated with traditional Chinese medicine. On the 14th day, serum level of endotoxin (ET), total bilirubin (TBil), alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood ammonia (NH3), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-10 (IL-10) were compared between the two groups. Outcomes of endotoxemia treatment, symptom score changes, and complications were also compared. Results: A total of 91 cases were followed up. After treatment, the level of ET in the observation group was lower than that of the control group (P<0.05). The levels of TBil, NH3, and IL-6 in the observation group were lower than those in the control group (P<0.05), but there was no statistical difference with regard to the ALT and AST (P> 0.05). The number of cases effectively treated in the observation group was more than that in the control group, and the difference between the groups was statistically significant (P<0.05). The improvement of symptoms in the observation group was better than that in the control group (P<0.05). There was no significant difference in complications between the two groups (P>0.05). Conclusion: The effect of retention enema therapy with traditional Chinese medicine for the treatment of liver cirrhosis related endotoxemia is of promising potential, and it can improve the clinical symptoms of patients and has good safety.
Key words
traditional Chinese medicine /
liver cirrhosis /
endotoxemia /
enema /
supplementary alternative medicine
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