代谢功能障碍相关脂肪性肝病(MASLD)是一种代谢相关的多系统疾病,是慢性肝病最常见的原因,亦是肝细胞癌发病的主要危险因素。相关研究指出,代谢性单纯性脂肪性肝病(MASL)向代谢性脂肪性肝炎(MASH)发展的这一病理过程,是MASLD进展到肝纤维化和肝癌的关键环节。徐春军教授师承名老中医关幼波,在“中州思想”“痰瘀理论”的基础上,认为此环节的主要原因是湿热蕴结,是本病病情进展的中间病机。基于此,本文总结徐春军教授临床辨治湿热蕴结型代谢相关脂肪性肝病(MAFLD)的独具特色的思路与方法,以期为MASLD的临床治疗提供有益的借鉴。
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a metabolic related multisystem disorder and has become the most common cause of chronic liver disease, as well as a major risk factor for hepatocellular carcinoma. Relevant studies indicate that the pathological progression from metabolic associated simple steatosis (MASL) to metabolic associated steatohepatitis (MASH) is a critical step in the advancement of MASLD to liver fibrosis and liver cancer. Professor Xu Chunjun, a disciple of the renowned traditional Chinese medicine practitioner Guan Youbo, based on the "Central Region Theory" and the "Phlegm-Stasis Theory", believes that the primary cause of this progression is the accumulation of damp-heat, which serves as an intermediate pathogenesis in the disease's progression. Based on this, this article summarizes Professor Xu's unique clinical approach and methods for diagnosing and treating damp-heat accumulation type MASLD, aiming to provide valuable insights for the clinical treatment of MASLD.
关键词
代谢相关脂肪性肝病 /
代谢功能障碍相关脂肪性肝病 /
湿热蕴结 /
治疗经验 /
中州理论
{{custom_keyword}} /
Key words
metabolic associated steatotic liver disease /
accumulation of dampness-heat /
therapeutic experience /
Zhongzhou Theory
{{custom_keyword}} /
中图分类号：
R259
{{custom_clc.code}}
({{custom_clc.text}})
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] Targher G, Byrne CD, Tilg H. MASLD: a systemic metabolic disorder with cardiovascular and malignant complications[J]. Gut, 2024, 73(4): 691-702.
[2] Dhamija E, Paul S,Kedia S. Non-alcoholic fatty liver disease associated with hepatocellular carcinoma:an increasing conc-ern[J]. Indian J Med Res, 2019, 149(1): 9-17.
[3] Younossi ZM, Koenig AB, Abdelatif D, et al. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes[J]. Hepatology (Baltimore, Md), 2016, 64(1): 73-84.
[4] 张莉,季光.非酒精性脂肪性肝病中医诊疗专家共识(2023)[J].中国中西医结合消化杂志, 2024, 32(1): 1-7.
[5] 王建梅. 非酒精性脂肪性肝炎中医证型与肝功能、血脂指标的相关性研究[D]. 浙江中医药大学, 2016.
[6] 张少鹏. 饮食习惯对非酒精性脂肪性肝病的影响及其中医证型与血脂、血糖的相关性研究[D]. 北京中医药大学, 2017.
[7] 宋翊,廖宇,严君,等.重庆市非酒精性脂肪性肝病中医证型规律及特点的研究[J].重庆医学,2017,46(18):2529-2531.
[8] 张声生, 李军祥. 非酒精性脂肪性肝病中医诊疗专家共识意见(2017)[J]. 中医杂志, 2017, 58(19): 1706-1710.
[9] 赵伯智.关幼波肝病杂病论[M].徐春军,钱英等,校.北京:中国医药科技出版社, 2013.
[10] 吴谦等,编. 医宗金鉴[M]. 北京:人民卫生出版社, 1963.
[11] 陈言. 三因极一病证方论[M].北京:中国中医药出版社, 2007.
[12] 朱震亨. 丹溪心法[M].北京:中国书店, 1986.
[13] 盛增秀. 王好古医学全书[M].北京:中国中医药出版社, 2015.
[14] 王孟英.王氏医案绎注[M].石念祖,注.北京:商务印书馆, 1957.
[15] 周鸿飞, 吕桂敏, 徐长卿. 温病条辨、温热论、湿热病篇、外感温病篇[M]. 郑州:河南科学技术出版社, 2017.
[16] 章楠. 医门棒喝[M].北京:中国医药科技出版社, 2019.
[17] 田思胜, 主编. 杂病源流犀烛[M].北京:人民卫生出版社, 2006.
{{custom_fnGroup.title_cn}}
脚注
{{custom_fn.content}}
PDF(3088 KB)
